1. - Anne Hathaway, The Princess Diaries, 2001. Among 22 youngstars (Drew Barrymore, Cameron Diaz, Reese Witherspoon, etc) rejecting the awkward San Francisco teenager being groomed (by Julie Andrews!) to inherit the Genovia throne - after director Garry Marshall’s (shock!) first choice of Juliette Lewis quit.
2. - Jodie Foster, Flightplan, 2004. When Sean Penn pulled out, the hero became the heroine - offered to Davis, Portia de Rossi, Christina Ricci... and Foster. The script still didn’t fly.
3. - Katherine Heigl, Knocked Up, 2007.