1. - Ruth Chatterton, The Laughing Lady, 1929. Having suffered a nervous breakdown (or too many drugs) during Jealousy, 1929, the self-made Broadway star (the greatest Sadie Thompson!), asked to be relieved of her next Paramount movie. The studio agreed - and she was dead before Ruth completed shooting.
2. - Nancy Carroll, The Devil's Holiday, 1930. Jeanne ODed on heroin before she could start the script written expressly for her by director Edmund Goulding. Nancy won an Oscar nod - and more fan mail than any other Parmount contract star that year.
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